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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM4
All Species:
39.39
Human Site:
Y193
Identified Species:
61.9
UniProt:
P33991
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33991
NP_005905.2
863
96558
Y193
I
D
I
T
E
P
L
Y
M
Q
R
L
G
E
I
Chimpanzee
Pan troglodytes
XP_528129
863
96543
Y193
I
D
I
T
E
P
L
Y
M
Q
R
L
G
E
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535063
929
104136
Y259
I
D
I
T
E
P
L
Y
M
Q
R
L
G
E
I
Cat
Felis silvestris
Mouse
Mus musculus
P49717
862
96718
Y192
I
D
I
T
Q
P
L
Y
M
Q
Q
L
G
E
I
Rat
Rattus norvegicus
NP_387500
862
96552
Y192
I
D
I
T
Q
P
L
Y
M
Q
R
L
G
E
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515513
863
97108
Y193
L
D
P
N
E
P
L
Y
M
Q
R
L
N
E
I
Chicken
Gallus gallus
XP_424376
859
96866
Y189
L
D
L
N
Q
P
R
Y
M
Q
R
L
E
E
I
Frog
Xenopus laevis
P30664
863
97105
Y193
L
D
L
N
E
P
I
Y
M
Q
R
L
E
E
I
Zebra Danio
Brachydanio rerio
NP_944595
750
84021
A128
A
V
A
G
D
Q
G
A
G
Q
R
L
V
I
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
Y196
I
D
V
N
Q
P
L
Y
L
Q
K
L
E
E
I
Honey Bee
Apis mellifera
XP_624670
636
71159
G14
L
S
A
T
D
S
P
G
R
T
P
R
R
Q
I
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
L137
L
D
E
Y
P
T
S
L
R
Q
V
K
S
A
Q
Sea Urchin
Strong. purpuratus
XP_801985
910
101460
Y238
I
N
P
H
E
P
L
Y
L
Q
K
L
E
E
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
D94
P
T
E
A
F
P
D
D
D
H
D
I
L
M
T
Baker's Yeast
Sacchar. cerevisiae
P30665
933
104985
Y226
T
T
D
E
E
L
Y
Y
I
K
Q
L
N
E
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
87.6
N.A.
94.9
95.1
N.A.
92.4
86.3
85.7
71.3
N.A.
60.1
42.1
28.1
63.3
Protein Similarity:
100
100
N.A.
90
N.A.
97
97.3
N.A.
96.1
93.1
92.9
78.7
N.A.
77.3
54.3
46.9
76.3
P-Site Identity:
100
100
N.A.
100
N.A.
86.6
93.3
N.A.
73.3
60
66.6
20
N.A.
60
13.3
13.3
60
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
80
80
86.6
26.6
N.A.
86.6
33.3
20
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.9
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.5
62.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
14
7
0
0
0
7
0
0
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
67
7
0
14
0
7
7
7
0
7
0
0
0
0
% D
% Glu:
0
0
14
7
47
0
0
0
0
0
0
0
27
74
0
% E
% Phe:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
0
7
7
7
0
0
0
34
0
0
% G
% His:
0
0
0
7
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
47
0
34
0
0
0
7
0
7
0
0
7
0
7
74
% I
% Lys:
0
0
0
0
0
0
0
0
0
7
14
7
0
0
0
% K
% Leu:
34
0
14
0
0
7
54
7
14
0
0
80
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
54
0
0
0
0
7
7
% M
% Asn:
0
7
0
27
0
0
0
0
0
0
0
0
14
0
0
% N
% Pro:
7
0
14
0
7
74
7
0
0
0
7
0
0
0
0
% P
% Gln:
0
0
0
0
27
7
0
0
0
80
14
0
0
7
7
% Q
% Arg:
0
0
0
0
0
0
7
0
14
0
54
7
7
0
0
% R
% Ser:
0
7
0
0
0
7
7
0
0
0
0
0
7
0
0
% S
% Thr:
7
14
0
40
0
7
0
0
0
7
0
0
0
0
7
% T
% Val:
0
7
7
0
0
0
0
0
0
0
7
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
7
0
0
7
74
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _